منابع مشابه
Antibody decoration of neurofilaments
We have decorated neurofilaments with antibodies against three polypeptides (designated here as H [mol wt = 195,000], 45[mol wt = 145,000], and 46[mol wt = 73,000]) in an effort to understand the arrangement of these polypeptides within neurofilaments. The three polypeptides were purified and antibodies were raised against each. The cross-reactivity of the antibodies suggested that each polypep...
متن کاملNeurofilaments.
maintenance of form. There is evidence that tropomyosin is present in neurons (Fine el al., 1973) and that it may be a smaller protein than muscle tropomyosin. The other ancillary proteins have so far not been rigorously identified. The way in which actin and myosin work in cells other than muscle is not known. There is little doubt that they are involved in some way with movements, and the str...
متن کاملSubmolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration.
Kinesin is a microtubule-activated ATPase thought to transport membrane-bounded organelles along MTs. To illuminate the structural basis for this function, EM was used to locate submolecular domains on bovine brain kinesin. Rotary shadowed kinesin appeared rod-shaped and approximately 80 nm long. One end of each molecule contained a pair of approximately 10 x 9 nm globular domains, while the op...
متن کاملNeurofilaments at a glance.
Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of neurons. Although they are present in perikarya and dendrites, neurofilaments are particularly abundant in axons, where they are essential for the radial growth of axons during development, the maintenance of axon caliber and the transmission of electrical impulses along axons, i.e. velocity of nerve co...
متن کاملOrganization of mammalian neurofilament polypeptides within the neuronal cytoskeleton
Neurofilaments in the axons of mammalian spinal cord neurons are extensively cross-linked; consequently, the filaments and their cross-bridges compose a three-dimensional lattice. We have used antibody decoration in situ combined with tissue preparation by the quick-freeze, deep-etch technique to locate three neurofilament polypeptides (195, 145, and 73 Kd) within this lattice. When antibodies ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1981
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.89.2.198